Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (622)
Related Products (622)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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[(pF)Phe4]Nociceptin(1-13)NH2
![[(pF)Phe4]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p1300.gif "Click to View [(pF)Phe4]Nociceptin(1-13)NH2 Product Detail")
0 ImagesCat. No.: HY-P1300CAS No.: 380620-88-2[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).
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[DAla2] Dynorphin A (1-9) (porcine)
![[DAla2] Dynorphin A (1-9) (porcine)](https://file.medchemexpress.com/product_pic/hy-p3646.gif "Click to View [DAla2] Dynorphin A (1-9) (porcine) Product Detail")
0 ImagesCat. No.: HY-P3646CAS No.: 95673-38-4[DAla2] Dynorphin A (1-9) (porcine) is a dynorphin, which can be used in studies of analgesic, addiction, and depression.
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GSK1521498
0 ImagesCat. No.: HY-19902CAS No.: 1426543-84-1GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents.
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Prodilidine hydrochloride
0 ImagesCat. No.: HY-105628ACAS No.: 3734-16-5Synonyms: CI-427 hydrochlorideProdilidine (CI-427) hydrochloride is a potent analgetic agent.
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Methocinnamox
0 ImagesCat. No.: HY-135698CAS No.: 117339-76-1Synonyms: M-CAMMethocinnamox (M-CAM) a selective and long-acting μ-opioid receptor (MOR) antagonist with a Ki of 0.6 nM. Methocinnamox binds to the orthosteric site of the MOR in a pseudo-irreversible, non-covalent manner, resulting in prolonged receptor blockade that persists until new receptors are synthesized. Methocinnamox acts as a reversible antagonist at both the kappa-opioid receptor (KOR) (Ki = 4.9 nM) and delta-opioid receptor (DOR) (Ki = 2.2 nM), and it exhibits no intrinsic agonist activity at these receptors. Methocinnamox can be used to reverse and prevent opioid overdose and addiction.
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Mu opioid receptor antagonist 9
0 ImagesCat. No.: HY-179282CAS No.: 3058600-77-1Mu opioid receptor antagonist 9 is potent, selective and CNS-pentrant mu-opioid receptor (MOR) antagonist with a Ki of 77.3 nM. Mu opioid receptor antagonist 9 exhibits selectivity over kappa-opioid receptor (KOR), and delta-opioid receptor (DOR). Mu opioid receptor antagonist 9 effectively blocks the antinociceptive effects of psychoactive substances. Mu opioid receptor antagonist 9 can reverse psychoactive substances-induced respiratory depression in mice. Mu opioid receptor antagonist 9 can be used for the research of Opioid Use Disorder (OUD).
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Trap-101 hydrochloride
0 ImagesCat. No.: HY-11052ACAS No.: 1216621-00-9Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ-, and δ-opioid receptors, respectively. Trap-101 attenuates motor deficits in a rat model of parkinson's disease and can be used for the research of nervous system diseases.
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(D-Met2,Pro5)-Enkephalinamide
0 ImagesCat. No.: HY-P3547CAS No.: 63307-63-1(D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity.
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Nalmefene Sulfate-d3
0 ImagesCat. No.: HY-W754114Nalmefene Sulfate-d3 is the deuterium labeled Nalmefene (HY-107744). Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders.
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Anrikefon
0 ImagesCat. No.: HY-P3445CAS No.: 2269511-95-5Synonyms: HSK21542Anrikefon is a peripherally restricted kappa opioid receptor (KOR) agonist, with an IC50 of 0.54 nM, an EC50 of 2.41 pM, and a Ka of 0.068 nM against human KOR, and it exhibits high selectivity over μ and δ opioid receptors. Anrikefon exerts analgesic effects by inhibiting behaviors associated with inflammatory, postoperative and neuropathic pain, and also exerts antipruritic effects by reducing itch-related behaviors. Anrikefon can be used in research on pain, pruritus, and pruritus associated with chronic kidney disease.
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SLL-022CCP
0 ImagesCat. No.: HY-184476CAS No.: 2084834-44-4SLL-022CCP is a KOR-selective, high affinity and extremely potent agonist with an EC50 of 9.1 nM and a Ki of 2.0 nM. SLL-022CCP inhibits cAMP production with an EC50 of 0.002 nM, and exhibits high receptor subtype selectivity over the μ-opioid receptor (MOR, EC50 = 1.6 nM) and δ-opioid receptor (DOR, EC50 = 30.0 nM). SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects.
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FK 33-824
0 ImagesCat. No.: HY-P2018CAS No.: 64854-64-4FK 33-824, a synthetic analogue of Met-enkephalin, is a selective agonist of the μ-opioid receptor (μ-OR).
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CSD-CH2(1,8)-NH2
0 ImagesCat. No.: HY-P5756CAS No.: 3032600-19-1CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (Ki: 6.8 nM). CSD-CH2(1,8)-NH2 inhibits calcium mobilization in DRG neurons. CH2(1,8)-NH2 antagonizes the antinociceptive effect of U50,488. CSD-CH2(1,8)-NH2 can be used for research of neuropsychiatric disorders.
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Naloxonazine
0 ImagesCat. No.: HY-137180CAS No.: 82824-01-9Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function.
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Vanilpyruvic acid (Standard)
0 ImagesCat. No.: HY-101416RCAS No.: 1081-71-6Synonyms: Vanylpyruvic acid (Standard)Vanilpyruvic acid (Standard) is the analytical standard of Vanilpyruvic acid. This product is intended for research and analytical applications. Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.
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Amdakefalin
0 ImagesCat. No.: HY-109166CAS No.: 2253747-71-4Amdakefalin is a μ and δ opioid receptors agonist with analgesic effects.
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μ/κ/δ opioid receptor agonist 1
0 ImagesCat. No.: HY-P10203μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test.
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Dafphedyn
0 ImagesCat. No.: HY-P2579CAS No.: 111846-43-6Dafphedyn is an analogue of Dynorphin (1-13). Dafphedyn has diuretic and profound analgesia effects that can be antagonized by centrally administered Naltrexone (HY-76711) or Naloxone (HY-17417A).
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BPR1M492
0 ImagesCat. No.: HY-184490CAS No.: 3118558-91-8BPR1M492 is a brain-penetrant μ-opioid receptor (MOR) agonist an in vitro EC50 of 0.93 nM in the cAMP inhibition assay and 0.004 nM in the FLIPR Ca2+ assay without a clear signaling bias between cAMP and β-arrestin-2 pathway. BPR1M492 is a cAMP-biased nociceptin-orphanin FQ opioid peptide agonist. BPR1M492 is a weak cAMP-biased δ/κ-opioid receptor agonist. BPR1M492 demonstrates potent in vivo antinociception and can be used for pain research.
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ZP 120C
0 ImagesCat. No.: HY-106234CAS No.: 383123-18-0ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia.
